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| Cat.No | ACP16625 | Target Name | THEMIS2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-643 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5TEJ8 |
|---|
Uniprot Id
Q5TEJ8
Target Species
Human
Target Name
THEMIS2
Target Full Name
Protein THEMIS2
Target Function
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
Themis family
Target Tissue Specificity
Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.
Target Synonyms
Basement membrane induced; Chromosome 1 open reading frame 38; ICB 1; ICB1; Induced by contact to basement membrane 1 protein; Protein ICB 1; Protein ICB-1; Protein THEMIS2; THEMIS2; THMS2_HUMAN; Thymocyte expressed molecule involved in selection protein 2; Thymocyte-expressed molecule involved in selection protein 2
Target Background
Predicted to be involved in T cell receptor signaling pathway and regulation of B cell activation. Predicted to be active in cytoplasm and nucleus.
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