Recombinant Human Protein transport protein Sec24D (SEC24D), Truncated

Uniprot Id

O94855

Target Species

Human

Target Name

SEC24D

Target Full Name

Protein transport protein Sec24D

Target Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5

Target Involvement

Cole-Carpenter syndrome 2 (CLCRP2)

Target Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.

Target Protein Families

SEC23/SEC24 family, SEC24 subfamily

Target Tissue Specificity

Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.

Target Synonyms

KIAA0755; Protein transport protein Sec24D; SC24D_HUMAN; SEC24 family member D; SEC24 related gene family; member D; SEC24-related protein D; SEC24D