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| Cat.No | ACP17384 | Target Name | EIPR1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-387 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q53HC9 |
|---|
Uniprot Id
Q53HC9
Target Species
Human
Target Name
EIPR1
Target Full Name
EARP and GARP complex-interacting protein 1
Target Function
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.
Target Subcellular Location
Golgi apparatus, trans-Golgi network.
Target Protein Families
WD repeat EIPR1 family
Target Synonyms
EIPR1; TSSC1EARP and GARP complex-interacting protein 1; Endosome-associated recycling protein-interacting protein; Golgi-associated retrograde protein-interacting protein; Tumor-suppressing STF cDNA 1 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein
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