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| Cat.No | ACP05837 | Target Name | UNC80 |
|---|---|---|---|
| Target Synonyms | C2orf21; Protein unc-80 homolog; UNC 80; Unc 80 homolog (C. elegans); Unc80; UNC80_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N2C7 |
|---|
Uniprot Id
Q8N2C7
Target Species
Human
Target Name
UNC80
Target Full Name
Protein unc-80 homolog
Target Function
Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.
Target Involvement
Hypotonia, infantile, with psychomotor retardation and characteristic facies 2 (IHPRF2)
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Unc-80 family
Target Tissue Specificity
Moderately expressed in fetal brain, spinal cord, skeletal muscle, thymus, spleen, fetal liver, small intestine, colon, kidney and uterus. Highly expressed in adrenal gland, prostate and testis, as well as in brain and cerebellum.
Target Synonyms
C2orf21; Protein unc-80 homolog; UNC 80; Unc 80 homolog (C. elegans); Unc80; UNC80_HUMAN
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