Recombinant Human Protein Wnt-2 (WNT2)

Uniprot Id

P09544

Target Species

Human

Target Name

WNT2

Target Full Name

Protein Wnt-2

Target Function

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted.

Target Protein Families

Wnt family

Target Tissue Specificity

Expressed in brain in the thalamus, in fetal and adult lung and in placenta.

Target Research Area

Cancer, Stem Cells

Target Synonyms

Int 1 related protein; Int-1-like protein 1; Int-1-related protein; INT1L 1; INT1L1; IRP; IRP protein; ONCOGENE INT1 LIKE 1; Protein Wnt-2; Secreted growth factor; Wingless type MMTV integration site family member 2; WNT 2; WNT2; WNT2_HUMAN

Target Background

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.