Recombinant Human Protein Wnt-7a (WNT7A)

Cat.No	ACP21500	Target Name	WNT7A
Target Synonyms	Protein Wnt-7a; Protein Wnt-7a precursor; Proto oncogene Wnt7a protein; proto-oncogene wnt7a protein; wingless-type MMTV integration site family; member 7A; Wnt family member 7A; WNT7A; WNT7A_HUMAN	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	32-349
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP21500

Target Name

WNT7A

Target Synonyms

Protein Wnt-7a; Protein Wnt-7a precursor; Proto oncogene Wnt7a protein; proto-oncogene wnt7a protein; wingless-type MMTV integration site family; member 7A; Wnt family member 7A; WNT7A; WNT7A_HUMAN

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

32-349

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O00755

Background Information

Uniprot Id

O00755
Target Species

Human
Target Name

WNT7A
Target Full Name

Protein Wnt-7a
Target Function

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5.
Target Involvement

Limb pelvis hypoplasia aplasia syndrome (LPHAS); Fuhrmann syndrome (FUHRS)
Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted.
Target Protein Families

Wnt family
Target Tissue Specificity

Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
Target Synonyms

Protein Wnt-7a; Protein Wnt-7a precursor; Proto oncogene Wnt7a protein; proto-oncogene wnt7a protein; wingless-type MMTV integration site family; member 7A; Wnt family member 7A; WNT7A; WNT7A_HUMAN
Target Background

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes.

Recombinant Human Protein Wnt-7a (WNT7A)

Specifications

Immunogen Information

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