Recombinant Human Protein Wnt-7b (Wnt7B)

Uniprot Id

P56706

Target Species

Human

Target Name

WNT7B

Target Full Name

Protein Wnt-7b

Target Function

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted.

Target Protein Families

Wnt family

Target Tissue Specificity

Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

Target Research Area

Cancer, Stem Cells

Target Synonyms

Protein Wnt-7b; Wingless related MMTV integration site 7B; Wingless type MMTV integration site family member 7B; WNT; WNT7B; WNT7B_HUMAN

Target Background

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein.