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Recombinant Human Protein XRP2 (RP2)

ACP03449

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Specifications

Cat.No	ACP03449	Target Name	RP2
Target Synonyms	RP2; Protein XRP2	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-350aa
Mol Weight	66.5kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O75695

Background Information

Uniprot Id

O75695
Target Species

Human
Target Name

RP2
Target Full Name

Protein XRP2
Target Function

Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Target Involvement

Retinitis pigmentosa 2 (RP2)
Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium.
Target Protein Families

TBCC family
Target Tissue Specificity

Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in t
Target Research Area

Neuroscience
Target Synonyms

RP2; Protein XRP2

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Recombinant Human Protein XRP2 (RP2)

Specifications

Immunogen Information

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