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The recombinant Human YPEL3 was expressed with the amino acid range of 1-119. The calculated molecular weight for this YPEL3 protein is 29.6 kDa. This protein is generated in a e.coli-based system. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of YPEL3, which enables a simple process of detecting and purifying the YPEL3 recombinant protein in the following steps.YPEL3, discovered in 2004, belongs to a family of Yippee proteins, comprising five members with conservation observed across various species, even extending to slime molds. YPEL3 has been recognized as a target gene of p53, demonstrating growth-suppressive characteristics by promoting senescence and apoptosis in diverse situations. It plays an important role in tumorigenesis. Numerous studies have shown that YPEL3 inhibits tumor growth, proliferation, and metastasis across various cancer types, including breast tumors and colon tumors.
The recombinant Human YPEL3 was expressed with the amino acid range of 1-119. The calculated molecular weight for this YPEL3 protein is 29.6 kDa. This protein is generated in a e.coli-based system. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of YPEL3, which enables a simple process of detecting and purifying the YPEL3 recombinant protein in the following steps.YPEL3, discovered in 2004, belongs to a family of Yippee proteins, comprising five members with conservation observed across various species, even extending to slime molds. YPEL3 has been recognized as a target gene of p53, demonstrating growth-suppressive characteristics by promoting senescence and apoptosis in diverse situations. It plays an important role in tumorigenesis. Numerous studies have shown that YPEL3 inhibits tumor growth, proliferation, and metastasis across various cancer types, including breast tumors and colon tumors.
| Cat.No | ACP04004 | Target Name | YPEL3 |
|---|---|---|---|
| Target Synonyms | Protein yippee-like 3; Small ubiquitinated apoptotic protein; Yippee like 3; Yippee-like 3 (Drosophila); Ypel3; YPEL3_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-119aa |
| Mol Weight | 29.6kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P61236 |
|---|
Uniprot Id
P61236
Target Species
Human
Target Name
YPEL3
Target Full Name
Protein yippee-like 3
Target Function
Involved in proliferation and apoptosis in myeloid precursor cells.
Target Subcellular Location
Nucleus, nucleolus.
Target Protein Families
Yippee family
Target Tissue Specificity
Widely expressed.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Protein yippee-like 3; Small ubiquitinated apoptotic protein; Yippee like 3; Yippee-like 3 (Drosophila); Ypel3; YPEL3_HUMAN
Target Background
Predicted to enable metal ion binding activity. Involved in positive regulation of cellular senescence. Predicted to be located in nucleolus.
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