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| Cat.No | ACP04569 | Target Name | FAM20A |
|---|---|---|---|
| Target Synonyms | FAM20A; UNQ9388/PRO34279Pseudokinase FAM20A | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 34-541aa |
| Mol Weight | 59.6kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96MK3 |
|---|
Uniprot Id
Q96MK3
Target Species
Human
Target Name
FAM20A
Target Full Name
Pseudokinase FAM20A
Target Function
Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.
Target Involvement
Amelogenesis imperfecta 1G (AI1G)
Target Subcellular Location
Secreted. Golgi apparatus. Endoplasmic reticulum.
Target Protein Families
FAM20 family
Target Tissue Specificity
Highly expressed in lung and liver. Intermediate levels in thymus and ovary.
Target Research Area
Cell Biology
Target Synonyms
FAM20A; UNQ9388/PRO34279Pseudokinase FAM20A
Target Background
This locus encodes a protein that is likely secreted and may function in hematopoiesis. A mutation at this locus has been associated with amelogenesis imperfecta and gingival hyperplasia syndrome. Alternatively spliced transcript variants have been identified.
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