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| Cat.No | ACP00774 | Target Name | TDRD12 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 447-635aa | Mol Weight | 28.9 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q587J7 |
|---|
Uniprot Id
Q587J7
Target Species
Human
Target Name
TDRD12
Target Full Name
Putative ATP-dependent RNA helicase TDRD12
Target Function
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
ECAT8; ES cell associated transcript 8; ES cell-associated transcript 8 protein; TDR12_HUMAN; Tdrd12; Tudor domain containing 12; Tudor domain-containing protein 12
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