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| Cat.No | ACP13058 | Target Name | TDRD9 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NDG6 |
|---|
Uniprot Id
Q8NDG6
Target Species
Human
Target Name
TDRD9
Target Full Name
ATP-dependent RNA helicase TDRD9
Target Function
ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.
Target Involvement
Defects in TDRD9 may be a cause of non-obstructive azoospermia, a disorder characterized by the absence of sperm. Female fertility is not affected.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
DEAD box helicase family, DEAH subfamily
Target Synonyms
C14orf75; chromosome 14 open reading frame 75; DKFZp434N0820; FLJ36164; HIG 1; Hypoxia inducible HIG 1; MGC135025; NET54; Putative ATP dependent RNA helicase TDRD9; Putative ATP-dependent RNA helicase TDRD9; TDRD 9; Tdrd9; TDRD9_HUMAN; Tudor domain containing 9; Tudor domain containing protein 9; Tudor domain-containing protein 9
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