Recombinant Human Putative histone-lysine N-methyltransferase PRDM6 (PRDM6)

Uniprot Id

Q9NQX0

Target Species

Human

Target Name

PRDM6

Target Full Name

Putative histone-lysine N-methyltransferase PRDM6

Target Function

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression

Target Involvement

Patent ductus arteriosus 3 (PDA3)

Target Subcellular Location

Nucleus.

Target Protein Families

Class V-like SAM-binding methyltransferase superfamily

Target Synonyms

Gm92; PFM3; PR domain containing 6; PR domain containing protein 6 ; PR domain zinc finger protein 6; PR domain-containing protein 6; Prdm6; PRDM6_HUMAN; PRISM; Putative histone-lysine N-methyltransferase PRDM6; RGD1559594

Target Background

The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3).