Recombinant Human Putative hydrolase RBBP9 (RBBP9)

Uniprot Id

O75884

Target Species

Human

Target Name

RBBP9

Target Full Name

Serine hydrolase RBBP9

Target Function

Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.

Target Protein Families

RBBP9 family

Target Tissue Specificity

Expressed at higher levels in tumor tissues such as carcinoma.

Target Synonyms

B5T overexpressed gene protein; B5T-overexpressed gene protein; BOG; Bog protein ; MGC9236; OTTHUMP00000030360; Protein BOG; Putative hydrolase RBBP9; RBBP 10; RBBP 9; RBBP-10; RBBP-9; RBBP10; RBBP9; RBBP9_HUMAN; Retinoblastoma binding protein 10; Retinoblastoma binding protein 9; Retinoblastoma-binding protein 10; Retinoblastoma-binding protein 9; Retinoma binding protein 9

Target Background

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.