Recombinant Human Putative Polycomb group protein ASXL1 (ASXL1), Truncated

Uniprot Id

Q8IXJ9

Target Species

Human

Target Name

ASXL1

Target Full Name

Polycomb group protein ASXL1

Target Function

Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing

Target Involvement

Bohring-Opitz syndrome (BOPS); Myelodysplastic syndrome (MDS)

Target Subcellular Location

Nucleus.

Target Protein Families

Asx family

Target Tissue Specificity

Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes.

Target Synonyms

Additional sex combs like 1 (Drosophila); Additional sex combs like protein 1; Additional sex combs-like protein 1; ASXL1; ASXL1_HUMAN; KIAA0978; Putative Polycomb group protein ASXL1