Recombinant Human Putative protein arginine N-methyltransferase 10 (PRMT10), Truncated

Uniprot Id

Q6P2P2

Target Species

Human

Target Name

PRMT9

Target Full Name

Protein arginine N-methyltransferase 9

Target Function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family

Target Synonyms

PRMT9; PRMT10; Protein arginine N-methyltransferase 9; Protein arginine N-methyltransferase 10; EC 2.1.1.320

Target Background

This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.