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| Cat.No | ACP13657 | Target Name | RBM15B |
|---|---|---|---|
| Target Synonyms | RBM15B; OTT3; Putative RNA-binding protein 15B; One-twenty two protein 3; HsOTT3; HuOTT3; RNA-binding motif protein 15B | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NDT2 |
|---|
Uniprot Id
Q8NDT2
Target Species
Human
Target Name
RBM15B
Target Full Name
Putative RNA-binding protein 15B
Target Function
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1
Target Subcellular Location
Nucleus, nucleoplasm. Nucleus speckle. Nucleus envelope.
Target Protein Families
RRM Spen family
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
RBM15B; OTT3; Putative RNA-binding protein 15B; One-twenty two protein 3; HsOTT3; HuOTT3; RNA-binding motif protein 15B
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