Recombinant Human PX domain-containing protein kinase-like protein (PXK)

Uniprot Id

Q7Z7A4

Target Species

Human

Target Name

PXK

Target Full Name

PX domain-containing protein kinase-like protein

Target Function

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

Target Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell.

Target Protein Families

Protein kinase superfamily

Target Tissue Specificity

Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.

Target Synonyms

FLJ20335; K-ATPase; Modulator of Na; Modulator of Na K ATPase ; Modulator of Na K ATPase long form ; MONaKA; PX domain containing protein kinase like protein ; PX domain containing serine/threonine kinase ; PX domain-containing protein kinase-like protein; PX ser/thr kinase v2 ; PX serine/threonine kinase ; Pxk; PXK_HUMAN

Target Background

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.