Recombinant Human Pyridoxal phosphate phosphatase (PDXP)

Cat.No	ACP04573	Target Name	Pdxp
Target Synonyms	Chronophin; CIN; Pdxp; PLP; PLP phosphatase; PLPP; PLPP_HUMAN; Pyridoxal (pyridoxine, vitamin B6) phosphatase; Pyridoxal phosphate phosphatase; Rbp1; Reg I binding protein 1; RP1 37E16.5	Form	Liquid or Lyophilized powder
Expression System	Yeast	Expression Range	1-296aa
Mol Weight	33.7kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04573

Target Name

Pdxp

Target Synonyms

Chronophin; CIN; Pdxp; PLP; PLP phosphatase; PLPP; PLPP_HUMAN; Pyridoxal (pyridoxine, vitamin B6) phosphatase; Pyridoxal phosphate phosphatase; Rbp1; Reg I binding protein 1; RP1 37E16.5

Form

Liquid or Lyophilized powder

Expression System

Yeast

Expression Range

1-296aa

Mol Weight

33.7kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96GD0

Background Information

Uniprot Id

Q96GD0
Target Species

Human
Target Name

PDXP
Target Full Name

Chronophin
Target Function

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine
Target Subcellular Location

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families

HAD-like hydrolase superfamily
Target Tissue Specificity

Ubiquitously expressed (at protein level). Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain.
Target Research Area

Signal Transduction
Target Synonyms

Chronophin; CIN; Pdxp; PLP; PLP phosphatase; PLPP; PLPP_HUMAN; Pyridoxal (pyridoxine, vitamin B6) phosphatase; Pyridoxal phosphate phosphatase; Rbp1; Reg I binding protein 1; RP1 37E16.5
Target Background

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).

Recombinant Human Pyridoxal phosphate phosphatase (PDXP)

Specifications

Immunogen Information

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