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The expression region of this recombinant Human PKLR covers amino acids 1-574. This PKLR protein is theoretically predicted to have a molecular weight of 65.8 kDa. This PKLR recombinant protein is manufactured in e.coli. The PKLR coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant PKLR protein in following stages of expression and purification.Human pyruvate kinase isozyme R/L (PKLR) is primarily found in the liver and red blood cells. It is involved in the final step of glycolysis, where it catalyzes the conversion of phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), generating pyruvate and ATP. In red blood cells, PKLR is crucial for energy production and maintaining cell integrity. Research on PKLR includes investigations into its role in glycolytic regulation, metabolic disorders, and its significance in various tissues. Mutations in the PKLR gene can lead to pyruvate kinase deficiency, a condition associated with hemolytic anemia.
The expression region of this recombinant Human PKLR covers amino acids 1-574. This PKLR protein is theoretically predicted to have a molecular weight of 65.8 kDa. This PKLR recombinant protein is manufactured in e.coli. The PKLR coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant PKLR protein in following stages of expression and purification.Human pyruvate kinase isozyme R/L (PKLR) is primarily found in the liver and red blood cells. It is involved in the final step of glycolysis, where it catalyzes the conversion of phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), generating pyruvate and ATP. In red blood cells, PKLR is crucial for energy production and maintaining cell integrity. Research on PKLR includes investigations into its role in glycolytic regulation, metabolic disorders, and its significance in various tissues. Mutations in the PKLR gene can lead to pyruvate kinase deficiency, a condition associated with hemolytic anemia.
| Cat.No | ACP04767 | Target Name | PKLR |
|---|---|---|---|
| Target Synonyms | red cell type; R type/L type pyruvate kinase; R-PK; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; RPK | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-574aa |
| Mol Weight | 65.8kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P30613 |
|---|
Uniprot Id
P30613
Target Species
Human
Target Name
PKLR
Target Full Name
Pyruvate kinase PKLR
Target Function
Plays a key role in glycolysis.
Target Involvement
Pyruvate kinase hyperactivity (PKHYP); Pyruvate kinase deficiency of red cells (PKRD)
Target Protein Families
Pyruvate kinase family
Target Research Area
Metabolism
Target Synonyms
EC 2.7.1.40; KPYR_HUMAN; L-PK; Pk-1; PK1 ; PKL ; Pklg; Pklr; PKR; PKRL; Pyruvate kinase 1; Pyruvate kinase isozymes R/L; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and red blood cell; Pyruvate kinase liver type; Pyruvate kinase type L; Pyruvate kinase, red cell type; R type/L type pyruvate kinase; R-PK; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; RPK
Target Background
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
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