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Recombinant Human R-spondin-2 (RSPO2)

ACP16206

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Specifications

Cat.No	ACP16206	Target Name	RSPO2
Target Synonyms	RSPO2; UNQ9384/PRO34209; R-spondin-2; Roof plate-specific spondin-2; hRspo2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	22-243
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6UXX9

Background Information

Uniprot Id

Q6UXX9
Target Species

Human
Target Name

RSPO2
Target Full Name

R-spondin-2
Target Function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.
Target Subcellular Location

Secreted.
Target Protein Families

R-spondin family
Target Synonyms

RSPO2; UNQ9384/PRO34209; R-spondin-2; Roof plate-specific spondin-2; hRspo2

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Recombinant Human R-spondin-2 (RSPO2)

Specifications

Immunogen Information

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