Recombinant Human RAD51-associated protein 1 (RAD51AP1)

Cat.No	ACP00737	Target Name	RAD51AP1
Target Synonyms	(HsRAD51AP1)(RAD51-interacting protein)	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-352aa
Mol Weight	39.4	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00737

Target Name

RAD51AP1

Target Synonyms

(HsRAD51AP1)(RAD51-interacting protein)

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-352aa

Mol Weight

39.4

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96B01

Background Information

Uniprot Id

Q96B01
Target Species

Human
Target Name

RAD51AP1
Target Full Name

RAD51-associated protein 1
Target Function

Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination. Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination. May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo.
Target Subcellular Location

Chromosome. Nucleus. Chromosome, telomere.
Target Tissue Specificity

Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes.
Target Research Area

Others
Target Synonyms

2510006L10Rik; MGC156698; OTTMUSP00000028651; PIR51; R51A1_HUMAN; RAB22; RAD51 associated protein 1; RAD51 interacting protein; RAD51-associated protein 1; RAD51-interacting protein; Rad51ap1

Recombinant Human RAD51-associated protein 1 (RAD51AP1)

Specifications

Immunogen Information

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