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| Cat.No | ACP12207 | Target Name | RHNO1 |
|---|---|---|---|
| Target Synonyms | RHNO1; C12orf32; RHINO; HKMT1188; RAD9; HUS1; RAD1-interacting nuclear orphan protein 1; RAD9; RAD1; HUS1-interacting nuclear orphan protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-238 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BSD3 |
|---|
Uniprot Id
Q9BSD3
Target Species
Human
Target Name
RHNO1
Target Full Name
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
Target Function
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
Target Subcellular Location
Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Target Tissue Specificity
Weakly expressed in testis, prostate, ovary, thymus and small intestine. Expressed strongly in breast cancer cells.
Target Synonyms
RHNO1; C12orf32; RHINO; HKMT1188; RAD9; HUS1; RAD1-interacting nuclear orphan protein 1; RAD9; RAD1; HUS1-interacting nuclear orphan protein
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