Recombinant Human Ragulator complex protein LAMTOR2 (LAMTOR2)

Uniprot Id

Q9Y2Q5

Target Species

Human

Target Name

LAMTOR2

Target Full Name

Ragulator complex protein LAMTOR2

Target Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2

Target Involvement

Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP)

Target Subcellular Location

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

GAMAD family

Target Synonyms

ENDAP ; Endosomal adaptor protein p14; HSPC003 ; LAMTOR2; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; Late endosomal/lysosomal Mp1 interacting protein; Late endosomal/lysosomal Mp1-interacting protein; LTOR2_HUMAN; MAPBPIP ; MAPKSP1 adaptor protein ; MAPKSP1AP ; Mitogen activated protein binding protein interacting protein ; Mitogen-activated protein-binding protein-interacting protein; p14; Ragulator complex protein LAMTOR2; Ragulator2; Roadblock domain containing 3; Roadblock domain containing protein 3 ; Roadblock domain-containing protein 3; ROBLD 3; robld3; RP11 336K24.9