Recombinant Human Ran-binding protein 10 (RANBP10)

Uniprot Id

Q6VN20

Target Species

Human

Target Name

RANBP10

Target Full Name

Ran-binding protein 10

Target Function

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.

Target Subcellular Location

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.

Target Protein Families

RANBP9/10 family

Target Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle.

Target Synonyms

FLJ31165; KIAA1464; RAN binding protein 10; Ran-binding protein 10; RanBP10; RBP10_HUMAN

Target Background

RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene.