Recombinant Human Ras and Rab interactor 1 (RIN1)

Uniprot Id

Q13671

Target Species

Human

Target Name

RIN1

Target Full Name

Ras and Rab interactor 1

Target Function

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Target Subcellular Location

Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Target Protein Families

RIN (Ras interaction/interference) family

Target Tissue Specificity

Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Target Synonyms

RIN1; Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1

Target Background

Predicted to enable small GTPase binding activity. Predicted to be involved in endocytosis; regulation of catalytic activity; and signal transduction. Predicted to act upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in cytoplasm and plasma membrane.