Recombinant Human Ras-related protein Rab-18 (RAB18)

Uniprot Id

Q9NP72

Target Species

Human

Target Name

RAB18

Target Full Name

Ras-related protein Rab-18

Target Function

Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.

Target Involvement

Warburg micro syndrome 3 (WARBM3)

Target Subcellular Location

Apical cell membrane. Lipid droplet.

Target Protein Families

Small GTPase superfamily, Rab family

Target Tissue Specificity

Ubiquitous.

Target Research Area

Signal Transduction

Target Synonyms

AA959686; RAB18; RAB18 small GTPase; RAB18; member RAS oncogene family; RAB18_HUMAN; RAB18LI1; Ras related protein Rab 18; Ras-asssociated protein RAB18; Ras-related protein Rab-18; RP11-148B2.1; WARBM3

Target Background

The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.