Recombinant Human Ras-related protein Rab-27B (RAB27B)

Uniprot Id

O00194

Target Species

Human

Target Name

RAB27B

Target Full Name

Ras-related protein Rab-27B

Target Function

Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes.

Target Subcellular Location

Membrane; Lipid-anchor. Late endosome.

Target Protein Families

Small GTPase superfamily, Rab family

Target Tissue Specificity

Expressed primarily in testis.

Target Research Area

Signal Transduction

Target Synonyms

C25KG; Rab27b; RAB27B member RAS oncogene family; RAS associated protein RAB27B; Ras related protein Rab 27b; Ras related protein Rab27b; Ras-related protein Rab-27B; RB27B_HUMAN; Small GTP binding protein rab27b

Target Background

Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle.