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| Cat.No | ACP13779 | Target Name | RITA1 |
|---|---|---|---|
| Target Synonyms | RITA1; C12orf52; RITA; PSEC0043; RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-269 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96K30 |
|---|
Uniprot Id
Q96K30
Target Species
Human
Target Name
RITA1
Target Full Name
RBPJ-interacting and tubulin-associated protein 1
Target Function
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Target Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
Target Protein Families
RITA family
Target Synonyms
RITA1; C12orf52; RITA; PSEC0043; RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein
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