Recombinant Human Receptor-type tyrosine-protein phosphatase H (PTPRH), Truncated

Cat.No	ACP12056	Target Name	PTPRH
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP12056

Target Name

PTPRH

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HD43

Background Information

Uniprot Id

Q9HD43
Target Species

Human
Target Name

PTPRH
Target Full Name

Receptor-type tyrosine-protein phosphatase H
Target Function

Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20
Target Subcellular Location

Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Cytoplasm.
Target Protein Families

Protein-tyrosine phosphatase family, Receptor class 3 subfamily
Target Tissue Specificity

Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differ
Target Synonyms

BEM 2; BEM2; Brain-enriched membrane-associated protein tyrosine phosphatase 2; Phosphotyrosine phosphatase; Protein tyrosine phosphatase receptor type H; PTPASE; PTPRH; PTPRH_HUMAN; R-PTP-H; Receptor-type tyrosine-protein phosphatase H; SAP-1; SAP1; Stomach cancer-associated protein tyrosine phosphatase 1; Transmembrane-type protein tyrosine phosphatase H; Transmembrane-type protein-tyrosine phosphatase type H

Recombinant Human Receptor-type tyrosine-protein phosphatase H (PTPRH), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Receptor-type tyrosine-protein phosphatase H (PTPRH), Truncated Now

Related Products