Recombinant Human Reelin (RELN), Truncated

Uniprot Id

P78509

Target Species

Human

Target Name

RELN

Target Full Name

Reelin

Target Function

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

Target Involvement

Lissencephaly 2 (LIS2); Epilepsy, familial temporal lobe, 7 (ETL7)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Reelin family

Target Tissue Specificity

Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in

Target Research Area

Cell Adhesion

Target Synonyms

LIS2; PRO1598; Reeler; Reelin; RELN; RELN_HUMAN; RL

Target Background

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.