Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A)

Uniprot Id

Q96P16

Target Species

Human

Target Name

RPRD1A

Target Full Name

Regulation of nuclear pre-mRNA domain-containing protein 1A

Target Function

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.

Target Protein Families

UPF0400 (RTT103) family

Target Synonyms

C77387; CDKN2B-related protein; Cyclin dependent kinase 2B inhibitor related protein; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) ; Cyclin dependent kinase inhibitor 2B related protein; Cyclin dependent kinase inhibitor related protein; Cyclin-dependent kinase inhibitor 2B-related protein; FLJ10656; HsT3101; Hypothetical protein FLJ10656; KIAA4077; MGC19513; MGC29396; MGC36325; mKIAA4077; p15INK4B related protein; p15INK4B-related protein; Putative uncharacterized protein P15RS; Regulation of nuclear pre mRNA domain containing 1A; Regulation of nuclear pre-mRNA domain-containing protein 1A; RGD1307374; RPR1A_HUMAN; RPRD1A

Target Background

This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16.