Recombinant Human Replication factor C subunit 3 (RFC3)

Uniprot Id

P40938

Target Species

Human

Target Name

RFC3

Target Full Name

Replication factor C subunit 3

Target Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Target Subcellular Location

Nucleus.

Target Protein Families

Activator 1 small subunits family

Target Synonyms

A1 38 kDa subunit; Activator 1 38 kDa subunit; Activator 1 subunit 3; HGNC:9971; MGC5276; Replication factor C (activator 1) 3; Replication factor C (activator 1) 3, 38kDa; Replication factor C 3; Replication factor C 38 kDa subunit; Replication factor C subunit 3; RF-C 38 kDa subunit; RFC 38 kD subunit; RFC 38 kDa subunit; RFC3; RFC3_HUMAN; RFC38

Target Background

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described.