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| Cat.No | ACP22083 | Target Name | ARHGAP10 |
|---|---|---|---|
| Target Synonyms | Arhgap10; Graf-related protein 2; GRAF2; GTPase regulator associated with focal adhesion kinase 2; PS GAP; PSGAP; RHG10_HUMAN; Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-786 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A1A4S6 |
|---|
Uniprot Id
A1A4S6
Target Species
Human
Target Name
ARHGAP10
Target Full Name
Rho GTPase-activating protein 10
Target Function
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.
Target Tissue Specificity
High levels of expression in heart and skeletal muscle.
Target Synonyms
Arhgap10; Graf-related protein 2; GRAF2; GTPase regulator associated with focal adhesion kinase 2; PS GAP; PSGAP; RHG10_HUMAN; Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10
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