Recombinant Human Rho GTPase-activating protein 17 (ARHGAP17), Truncated

Uniprot Id

Q68EM7

Target Species

Human

Target Name

ARHGAP17

Target Full Name

Rho GTPase-activating protein 17

Target Function

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Target Subcellular Location

Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.

Target Tissue Specificity

Ubiquitously expressed. Expressed at higher level in heart and placenta.

Target Synonyms

ARHGAP17; RICH1; MSTP066; MSTP110; Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1