Recombinant Human Rho guanine nucleotide exchange factor 26 (ARHGEF26), Truncated

Uniprot Id

Q96DR7

Target Species

Human

Target Name

ARHGEF26

Target Full Name

Rho guanine nucleotide exchange factor 26

Target Function

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

Target Subcellular Location

Cell projection, ruffle.

Target Tissue Specificity

Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.

Target Synonyms

ARHGEF26; SGEF; HMFN1864; Rho guanine nucleotide exchange factor 26; SH3 domain-containing guanine exchange factor

Target Background

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.