Recombinant Human Rhodopsin (RHO), Truncated

Uniprot Id

P08100

Target Species

Human

Target Name

RHO

Target Full Name

Rhodopsin

Target Function

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling.

Target Involvement

Retinitis pigmentosa 4 (RP4); Night blindness, congenital stationary, autosomal dominant 1 (CSNBAD1)

Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment.

Target Protein Families

G-protein coupled receptor 1 family, Opsin subfamily

Target Tissue Specificity

Rod shaped photoreceptor cells which mediate vision in dim light.

Target Research Area

Signal Transduction

Target Synonyms

CSNBAD1; MGC138309; MGC138311; OPN 2; OPN2; opsd; OPSD_HUMAN; opsin 2; Opsin 2 rod pigment; Opsin-2; Opsin2; Retinitis Pigmentosa 4; Retinitis pigmentosa 4 autosomal dominant; RHO; Rhodopsin; RP 4; RP4

Target Background

The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness.