Recombinant Human Rhombotin-1 (LMO1)

Cat.No	ACP23869	Target Name	LMO1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-156	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP23869

Target Name

LMO1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-156

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P25800

Background Information

Uniprot Id

P25800
Target Species

Human
Target Name

LMO1
Target Full Name

Rhombotin-1
Target Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Target Involvement

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Cysteine rich protein TTG 1; Cysteine rich protein TTG1; Cysteine-rich protein TTG-1; LIM domain only 1; LIM domain only protein 1; LMO 1; LMO-1; lmo1; MGC116692; RBTN 1; RBTN1; RBTN1_HUMAN; RHOM 1; RHOM1; Rhombotin 1; Rhombotin-1; Rhombotin1; T cell translocation protein 1; T-cell translocation protein 1; TTG 1; TTG1
Target Background

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.

Recombinant Human Rhombotin-1 (LMO1)

Specifications

Immunogen Information

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