Recombinant Human Ribonuclease H2 subunit B (RNASEH2B)

Uniprot Id

Q5TBB1

Target Species

Human

Target Name

RNASEH2B

Target Full Name

Ribonuclease H2 subunit B

Target Function

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

Target Involvement

Aicardi-Goutieres syndrome 2 (AGS2)

Target Subcellular Location

Nucleus.

Target Protein Families

RNase H2 subunit B family

Target Tissue Specificity

Widely expressed.

Target Synonyms

RNASEH2B; DLEU8; Ribonuclease H2 subunit B; RNase H2 subunit B; Aicardi-Goutieres syndrome 2 protein; AGS2; Deleted in lymphocytic leukemia 8; Ribonuclease HI subunit B

Target Background

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).