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| Cat.No | ACP01549 | Target Name | RNH1 |
|---|---|---|---|
| Target Synonyms | (Placental ribonuclease inhibitor)(Placental RNase inhibitor)(Ribonuclease/angiogenin inhibitor 1)(RAI) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-461aa |
| Mol Weight | 53.9 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P13489 |
|---|
Uniprot Id
P13489
Target Species
Human
Target Name
RNH1
Target Full Name
Ribonuclease inhibitor
Target Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
Target Subcellular Location
Cytoplasm.
Target Research Area
Cardiovascular
Target Synonyms
AW546468; C80305; MGC18200; MGC4569; MGC54054; OTTHUMP00000147628; OTTHUMP00000229864; OTTHUMP00000229865; OTTHUMP00000229866; OTTHUMP00000229870; OTTHUMP00000229871; OTTHUMP00000229872; Placental ribonuclease inhibitor; Placental RNase inhibitor; PRI; RAI; RI; Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1; Ribonuclease/angiogenin inhibitor; RINI_HUMAN; RNase inhibitor; RNH 1; RNH; RNH1; Rnh1 ribonuclease/angiogenin inhibitor 1
Target Background
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50, 000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.
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