Recombinant Human Ribosome-releasing factor 2, mitochondrial (GFM2)

Uniprot Id

Q969S9

Target Species

Human

Target Name

GFM2

Target Full Name

Ribosome-releasing factor 2, mitochondrial

Target Function

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.

Target Subcellular Location

Mitochondrion.

Target Protein Families

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily

Target Tissue Specificity

Widely expressed.

Target Synonyms

GFM2; EFG2; MSTP027; Ribosome-releasing factor 2; mitochondrial; RRF2mt; Elongation factor G 2; mitochondrial; EF-G2mt; mEF-G 2; Elongation factor G2; hEFG2

Target Background

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms.