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| Cat.No | ACP08525 | Target Name | RNF183 |
|---|---|---|---|
| Target Synonyms | RNF183; E3 ubiquitin-protein ligase RNF183 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96D59 |
|---|
Uniprot Id
Q96D59
Target Species
Human
Target Name
RNF183
Target Full Name
E3 ubiquitin-protein ligase RNF183
Target Function
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum. Golgi apparatus, cis-Golgi network membrane. Lysosome membrane.
Target Tissue Specificity
Kidney and testis.
Target Synonyms
RNF183; E3 ubiquitin-protein ligase RNF183
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