Recombinant Human RING finger protein 212 (RNF212)

Uniprot Id

Q495C1

Target Species

Human

Target Name

RNF212

Target Full Name

Probable E3 SUMO-protein ligase RNF212

Target Function

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.

Target Subcellular Location

Nucleus. Chromosome.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

FLJ38841; Hypothetical protein LOC285498; LOC285498; OTTHUMP00000147525; Probable E3 SUMO-protein ligase RNF212; RING finger protein 212; RN212_HUMAN; RNF 212; RNF212; ZHP3 ; ZHP3; C. elegans; homolog of; ZIP3-related protein

Target Background

This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.