Home Products Recombinant Human RING finger protein 26 (RNF26), Truncated

Recombinant Human RING finger protein 26 (RNF26), Truncated

ACP08479

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Specifications

Cat.No	ACP08479	Target Name	RNF26
Target Synonyms	RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9BY78

Background Information

Uniprot Id

Q9BY78
Target Species

Human
Target Name

RNF26
Target Full Name

E3 ubiquitin-protein ligase RNF26
Target Function

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Tissue Specificity

Ubiquitous. Up-regulated in several cancer cell lines.
Target Synonyms

RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26

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Recombinant Human RING finger protein 26 (RNF26), Truncated

Specifications

Immunogen Information

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