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Recombinant Human RNA-binding protein MEX3C (MEX3C)

ACP16754

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Specifications

Cat.No	ACP16754	Target Name	MEX3C
Target Synonyms	BM 013; BM013; FLJ38871; Mex 3 homolog C C. elegans ; Mex 3, C. elegans	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-659
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q5U5Q3

Background Information

Uniprot Id

Q5U5Q3
Target Species

Human
Target Name

MEX3C
Target Full Name

RNA-binding E3 ubiquitin-protein ligase MEX3C
Target Function

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Target Involvement

Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.
Target Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
Target Tissue Specificity

Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.
Target Synonyms

BM 013; BM013; FLJ38871; Mex 3 homolog C C. elegans ; Mex 3, C. elegans, homolog of C; MEX 3C; MEX3C; MEX3C_HUMAN; Ring finger and KH domain containing 2 ; RING finger and KH domain containing protein 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RKHD2; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C; RNF194

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Recombinant Human RNA-binding protein MEX3C (MEX3C)

Specifications

Immunogen Information

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