Recombinant Human RNA-binding protein NOB1 (NOB1)

Uniprot Id

Q9ULX3

Target Species

Human

Target Name

NOB1

Target Full Name

RNA-binding protein NOB1

Target Function

May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.

Target Subcellular Location

Nucleus.

Target Protein Families

NOB1 family

Target Tissue Specificity

Detected in liver, lung, placenta, endothelial cells and spleen.

Target Synonyms

Adenocarcinoma antigen recognized by T lymphocytes 4 ; ART 4; ART4; MST158; MSTP158; Nin one binding protein ; NIN1/PSMD8 binding protein 1 homolog; NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); nob1; NOB1_HUMAN; NOB1P; Phosphorylation regulatory protein HP-10; Protein ART-4; Protein ART4; PSMD8 binding protein 1 ; PSMD8BP1; RNA binding protein NOB1; RNA-binding protein NOB1

Target Background

In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).