Recombinant Human S-adenosylmethionine synthase isoform type-1 (MAT1A)

Uniprot Id

Q00266

Target Species

Human

Target Name

MAT1A

Target Full Name

S-adenosylmethionine synthase isoform type-1

Target Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

Target Involvement

Methionine adenosyltransferase deficiency (MATD)

Target Protein Families

AdoMet synthase family

Target Tissue Specificity

Expressed in liver.

Target Research Area

Signal Transduction

Target Synonyms

MAT1A; AMS1; MATA1S-adenosylmethionine synthase isoform type-1; AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III

Target Background

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.