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This Recombinant Human SKP1 protein is a valuable tool for researchers in the field of cell biology. S-phase kinase-associated protein 1 (SKP1) is a core component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, playing a crucial role in cell cycle progression, signal transduction, and ubiquitin-mediated proteolysis. Our Recombinant Human SKP1 protein is expressed in E.coli, yielding the full length of mature protein (2-163aa) while maintaining its native structure and function. Featuring a C-terminal GST-tag, this protein enables efficient purification and detection, providing consistent and reliable results for your research. The purity of our Recombinant Human SKP1 protein is greater than 90%, as determined by SDS-PAGE, ensuring a high-quality product for your experiments. Available in both liquid and lyophilized powder formats, this protein is designed to meet the diverse requirements of your research.
This Recombinant Human SKP1 protein is a valuable tool for researchers in the field of cell biology. S-phase kinase-associated protein 1 (SKP1) is a core component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, playing a crucial role in cell cycle progression, signal transduction, and ubiquitin-mediated proteolysis.
Our Recombinant Human SKP1 protein is expressed in E.coli, yielding the full length of mature protein (2-163aa) while maintaining its native structure and function. Featuring a C-terminal GST-tag, this protein enables efficient purification and detection, providing consistent and reliable results for your research. The purity of our Recombinant Human SKP1 protein is greater than 90%, as determined by SDS-PAGE, ensuring a high-quality product for your experiments. Available in both liquid and lyophilized powder formats, this protein is designed to meet the diverse requirements of your research.
| Cat.No | ACP03948 | Target Name | SKP1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-163aa | Mol Weight | 45.5kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P63208 |
|---|
Uniprot Id
P63208
Target Species
Human
Target Name
SKP1
Target Full Name
S-phase kinase-associated protein 1
Target Function
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.
Target Protein Families
SKP1 family
Target Research Area
Cell Biology
Target Synonyms
Cyclin A/CDK2 associated p19; Cyclin A/CDK2 associated protein p19; Cyclin-A/CDK2-associated protein p19; EMC19; MGC34403; OCP 2; OCP II; OCP II protein; OCP-2; OCP-II; OCP2; OCPII; Organ of Corti protein 2; Organ of Corti protein II; OTTHUMP00000159379; OTTHUMP00000159380; OTTHUMP00000228275; OTTHUMP00000228276; OTTHUMP00000228278; OTTHUMP00000228279; OTTHUMP00000228281; p19A; p19skp1; RNA polymerase II elongation factor like protein; RNA polymerase II elongation factor like protein OCP2; RNA polymerase II elongation factor-like protein; S phase kinase associated protein 1; S phase kinase associated protein 1A; S phase kinase associated protein 1A p19A; S-phase kinase-associated protein 1; SIII; Skp 1; SKP 1A; skp1; SKP1_HUMAN; SKP1A; TCEB1L; Transcription Elongation Factor B 1 like; Transcription elongation factor B; Transcription elongation factor B SIII polypeptide 1 like
Target Background
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
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