Recombinant Human Schlafen family member 11 (SLFN11)

Uniprot Id

Q7Z7L1

Target Species

Human

Target Name

SLFN11

Target Full Name

Schlafen family member 11

Target Function

Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.

Target Subcellular Location

Nucleus. Chromosome.

Target Protein Families

Schlafen family

Target Tissue Specificity

Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.

Target Research Area

Cell Biology

Target Synonyms

SLFN11; Schlafen family member 11; EC 3.6.-.-

Target Background

Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage.