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| Cat.No | ACP00407 | Target Name | SOSTDC1 |
|---|---|---|---|
| Target Synonyms | Ectodermal BMP inhibitor ;EctodinUterine sensitization-associated gene 1 protein ;USAG-1 | Form | Liquid or Lyophilized powder |
| Expression System | Mammalian cell | Expression Range | 24-206aa |
| Mol Weight | 49.7 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6X4U4 |
|---|
Uniprot Id
Q6X4U4
Target Species
Human
Target Name
SOSTDC1
Target Full Name
Sclerostin domain-containing protein 1
Target Function
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Target Subcellular Location
Secreted.
Target Protein Families
Sclerostin family
Target Tissue Specificity
Highly expressed in kidney and weakly in lung.
Target Research Area
Signal Transduction
Target Synonyms
CDA019; DKFZp564D206; Ectodermal BMP inhibitor; Ectodin; sclerostin domain containing 1; Sclerostin domain containing protein 1; Sclerostin domain-containing protein 1; SOSD1_HUMAN; Sostdc1; USAG-1; USAG1; Uterine sensitization associated gene 1 protein; Uterine sensitization-associated gene 1 protein; Wise
Target Background
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.
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